Thiamphenicol-d3

Modify Date: 2024-01-11 20:59:09

Thiamphenicol-d3 structure	Common Name	Thiamphenicol-d3
	CAS Number	2211914-19-9	Molecular Weight	359.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₂D₃Cl₂NO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thiamphenicol-d3

Thiamphenicol-d3 is deuterium labeled Thiamphenicol. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].

Name	Thiamphenicol-d3

Description	Thiamphenicol-d3 is deuterium labeled Thiamphenicol. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. A Marchese, et al. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61. [3]. Marta Tikhomirov, et al. Pharmacokinetics of florfenicol and thiamphenicol in ducks. J Vet Pharmacol Ther. 2019 Jan;42(1):116-120.

Molecular Formula	C₁₂H₁₂D₃Cl₂NO₅S
Molecular Weight	359.24

Thiamphenicol-d3

Use of Thiamphenicol-d3

Names

Thiamphenicol-d3 Biological Activity

Chemical & Physical Properties