PAD2-IN-1

Modify Date: 2024-01-15 19:20:51

PAD2-IN-1 structure	Common Name	PAD2-IN-1
	CAS Number	2095109-82-1	Molecular Weight	480.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₉FN₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PAD2-IN-1

PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

Name	PAD2-IN-1

Description	PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
Target	Protein Arginine Deiminase 2 (PAD2)[1]
In Vitro	In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1]. PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].
References	[1]. Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211.

Molecular Formula	C₂₅H₂₉FN₆O₃
Molecular Weight	480.53