2095109-82-1
2095109-82-1 structure
- Name: PAD2-IN-1
- Chemical Name: PAD2-IN-1
- CAS Number: 2095109-82-1
- Molecular Formula: C25H29FN6O3
- Molecular Weight: 480.53
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2020-08-08 11:11:29
- Modify Date: 2024-01-15 19:20:51
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PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].
| Name | PAD2-IN-1 |
|---|
| Description | PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1]. |
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| Related Catalog | |
| Target |
Protein Arginine Deiminase 2 (PAD2)[1] |
| In Vitro | In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1]. PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1]. |
| References |
| Molecular Formula | C25H29FN6O3 |
|---|---|
| Molecular Weight | 480.53 |