2095107-57-4

2095107-57-4 structure

Name: PAD2-IN-2
Chemical Name: CAY10723
CAS Number: 2095107-57-4
Molecular Formula: C₂₄H₂₇FN₆O₃
Molecular Weight: 466.508
Catalog: Research Areas Cancer
Create Date: 2021-05-07 17:54:30
Modify Date: 2024-01-03 16:46:01
PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1].

Name	CAY10723
Synonyms	N-[(1S)-4-{[(1Z)-2-Fluoroethanimidoyl]amino}-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-3-oxo-4-isoindolinecarboxamide CAY10723 1H-Isoindole-4-carboxamide, N-[(1S)-4-[[(1Z)-2-fluoro-1-iminoethyl]amino]-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo-

Description	PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
Target	PAD2
In Vitro	PAD2-IN-2 (compound 37a; 25 μM; HEK293T/PAD2 cells) exhibits good potency with >60% occupancy in target engagement assay[1]. PAD2-IN-2 (0, 1, 5, 10, 25μM ; 72 h) enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM[1]. PAD2-IN-2 (0, 1, 5, 10, 25μM, 3 h) inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells[1].
In Vivo	PAD2-IN-2 (AMF30a) protects K. pneumonia pneumonia mice from Imipenem-induced mortality increase[2].
References	[1]. Muth A, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211. [2]. Ye C, et al. Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection. Cell Rep. 2021 Sep 21;36(12):109750.