AChE/BChE/BACE-1-IN-2
Modify Date: 2024-01-12 17:29:33
AChE/BChE/BACE-1-IN-2 structure
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Common Name | AChE/BChE/BACE-1-IN-2 | ||
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| CAS Number | 1877000-20-8 | Molecular Weight | 302.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H20F2N2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AChE/BChE/BACE-1-IN-2AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1]. |
| Name | AChE/BChE/BACE-1-IN-2 |
|---|
| Description | AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1]. |
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| Related Catalog | |
| Target |
IC50: 0.069 μM (hAChE), 0.097 μM (hBACE-1), 0.127 μM (hBChE)[1] |
| In Vivo | AChE/BChE/BACE-1-IN-2 (Compound 4o) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1]. |
| References |
| Molecular Formula | C18H20F2N2 |
|---|---|
| Molecular Weight | 302.36 |