2761542-55-4

2761542-55-4 structure

Name: AChE/BChE-IN-9
Chemical Name: AChE/BChE-IN-9
CAS Number: 2761542-55-4
Molecular Formula: C₂₀H₁₉N₃O₄
Molecular Weight: 365.38
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-06-26 09:52:31
Modify Date: 2024-01-14 17:44:35
AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].

Name	AChE/BChE-IN-9

Description	AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 5.74 μM (AChE), 14.05 μM (BChE)[1]
In Vivo	AChE/BChE-IN-9 (Compound 7a) (0-25 mg/kg) improves spatial memory in cognitive deficit mice[1].
References	[1]. Singh YP, et al. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease. Eur J Med Chem. 2020 Jul 15;198:112257.

Molecular Formula	C₂₀H₁₉N₃O₄
Molecular Weight	365.38