Monomethyl fumarate-d5

Modify Date: 2024-01-09 11:20:52

Monomethyl fumarate-d5 structure	Common Name	Monomethyl fumarate-d5
	CAS Number	1616345-45-9	Molecular Weight	135.13
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅HD₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Monomethyl fumarate-d5

Monomethyl fumarate-d5 is deuterium labeled Monomethyl fumarate. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

Name	Monomethyl fumarate-d5

Description	Monomethyl fumarate-d5 is deuterium labeled Monomethyl fumarate. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR109A Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. [3]. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. [4]. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432.

Molecular Formula	C₅HD₅O₄
Molecular Weight	135.13

Monomethyl fumarate-d5

Use of Monomethyl fumarate-d5

Names

Monomethyl fumarate-d5 Biological Activity

Chemical & Physical Properties