Lenampicillin-d5 hydrochloride

Modify Date: 2024-01-10 20:58:54

Lenampicillin-d5 hydrochloride structure	Common Name	Lenampicillin-d5 hydrochloride
	CAS Number	1356847-85-2	Molecular Weight	502.98
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉D₅ClN₃O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lenampicillin-d5 hydrochloride

Lenampicillin-d5 (KBT 1585-d5) hydrochloride is the deuterium labeled Lenampicillin hydrochloride. Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active prodrug of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection[1][2][3].

Name	Lenampicillin-d5 hydrochloride

Description	Lenampicillin-d5 (KBT 1585-d5) hydrochloride is the deuterium labeled Lenampicillin hydrochloride. Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active prodrug of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. FUMIO OGINO, et al. ACUTE TOXICITY OF LENAMPICILLIN HYDROCHLORIDE (KBT-1585) IN MICE, RATS AND DOGS [3]. Yamabe S, et al. Non-mutagenicity of KBT-1585, a novel ester of ampicillin.Chemioterapia. 1984 Feb;3(1):60-2. [4]. Fujita K, et al. Clinical evaluation of lenampicillin in the treatment of superficial suppurative skin and soft tissue infection. A double-blind study comparing amoxicillin.Jpn J Antibiot. 1985 Jul;38(7):1794-818.

Molecular Formula	C₂₁H₁₉D₅ClN₃O₇S
Molecular Weight	502.98

Lenampicillin-d5 hydrochloride

Use of Lenampicillin-d5 hydrochloride

Names

Lenampicillin-d5 hydrochloride Biological Activity

Chemical & Physical Properties