L-651,582

Modify Date: 2024-01-04 12:12:41

L-651,582 Structure
L-651,582 structure
Common Name L-651,582
CAS Number 99519-84-3 Molecular Weight 424.67
Density 1.65g/cm3 Boiling Point 685.5ºC at 760 mmHg
Molecular Formula C17H12Cl3N5O2 Melting Point N/A
MSDS Chinese USA Flash Point 368.3ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of L-651,582


Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2].

 Names

Name 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide
Synonym More Synonyms

 L-651,582 Biological Activity

Description Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2].
Related Catalog
Target

Calcium channel[1]

References

[1]. Chen C, et al. Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017 Aug;362(2):219-229.

[2]. Hussain MM, et al. J Clin Oncol. 2003 Dec 1;21(23):4356-63.

 Chemical & Physical Properties

Density 1.65g/cm3
Boiling Point 685.5ºC at 760 mmHg
Molecular Formula C17H12Cl3N5O2
Molecular Weight 424.67
Flash Point 368.3ºC
Exact Mass 423.00600
PSA 116.89000
LogP 4.48020
Index of Refraction 1.73

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T+
RIDADR UN 2811 6.1 / PGIII

 Synthetic Route

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 Synonyms

4-CAI
CAI
Carboxyamido-triazole
Carboxyamidotriazole