L-651,582

Names

[ Name ]:
L-651,582

[Synonym ]:
4-CAI
CAI
Carboxyamido-triazole
Carboxyamidotriazole

Biological Activity

[Description]:

Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

Calcium channel[1]

[References]

[1]. Chen C, et al. Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017 Aug;362(2):219-229.

[2]. Hussain MM, et al. J Clin Oncol. 2003 Dec 1;21(23):4356-63.

Chemical & Physical Properties

[ Density]:
1.65g/cm3

[ Boiling Point ]:
685.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂Cl₃N₅O₂

[ Molecular Weight ]:
424.67

[ Flash Point ]:
368.3ºC

[ Exact Mass ]:
423.00600

[ PSA ]:
116.89000

[ LogP ]:
4.48020

[ Index of Refraction ]:
1.73

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
T+

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Comparison of the applicability of mass spectrometer ion sources using a polarity- molecular weight scattergram with a 600 sample in-house chemical library.

Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 91-6, (2015)

To provide a practical guideline for the selection of a mass spectrometer ion source, we compared the applicability of three types of ion source: direct analysis in real time (DART), electrospray ioni...

Differentially expressed and activated proteins associated with non small cell lung cancer tissues.

Respir. Res. 16 , 74, (2015)

Lung cancer is a leading cause of mortality. The most common cancer subtype, non small cell lung cancer (NSCLC), accounts for 85-90% all cases and is mainly caused by environmental and genetic factors...

Intergenerational cultural conflict, mental health, and educational outcomes among Asian and Latino/a Americans: Qualitative and meta-analytic review.

Psychol. Bull. 141(2) , 404-46, (2015)

Among immigrant Asian and Latino groups, the contrast between collectivism in traditional heritage and individualism in the mainstream American cultures presents unique challenges for their family rel...

Related Compounds

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