Pyruvic acid-13C

Modify Date: 2024-01-11 20:43:52

Pyruvic acid-13C Structure
Pyruvic acid-13C structure
Common Name Pyruvic acid-13C
CAS Number 99124-30-8 Molecular Weight 89.05470
Density N/A Boiling Point N/A
Molecular Formula C3H4O3 Melting Point N/A
MSDS Chinese USA Flash Point 179.6 °F
Symbol GHS05
GHS05
Signal Word Danger

 Use of Pyruvic acid-13C


Pyruvic acid-13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].

 Names

Name 2-oxopropanoic acid
Synonym More Synonyms

 Pyruvic acid-13C Biological Activity

Description Pyruvic acid-13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Kładna A, et al. Reactivity of pyruvic acid and its derivatives towards reactive oxygen species. Luminescence. 2015 Nov;30(7):1153-8.  

 Chemical & Physical Properties

Molecular Formula C3H4O3
Molecular Weight 89.05470
Exact Mass 89.01940
PSA 54.37000

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
RIDADR UN 3265 8 / PGII
Flash Point(F) 179.6 °F
Flash Point(C) 82 °C

 Synthetic Route

~97%

Pyruvic acid-13C Structure

Pyruvic acid-13C

CAS#:99124-30-8

Literature: Spectra Gases, Inc. Patent:   US2008/161593 A1, 2008 ; Location in patent: Page/Page column 11-12 ;

~79%

Pyruvic acid-13C Structure

Pyruvic acid-13C

CAS#:99124-30-8

Literature: AMERSHAM HEALTH AS Patent:   WO2006/38811 A1, 2006 ; Location in patent: Page/Page column 7; 8 ;

~%

Pyruvic acid-13C Structure

Pyruvic acid-13C

CAS#:99124-30-8

Literature: The Regents of the University of California Patent:   US2006/178534 A1, 2006 ; Location in patent: Page/Page column 4-5 ;

 Articles2

More Articles
Using [1-(13) C]lactic acid for hyperpolarized (13) C MR cardiac studies.

Magn. Reson. Med. , doi:10.1002/mrm.2535, (2014)

Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]...

Enhancing the [13C]bicarbonate signal in cardiac hyperpolarized [1-13C]pyruvate MRS studies by infusion of glucose, insulin and potassium.

NMR Biomed. 26(11) , 1496-500, (2013)

A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, ...

 Synonyms

2-Oxopropionic acid-1-13C
|A-Ketopropionic acid-1-13C
Pyruvic-1-13C acid (free acid)
Pyruvic acid-1-13C
13C Labeled pyruvic acid
PYRUVIC-1-13C ACID (FREE ACID)