Pyruvic acid-13C

Names

[ Name ]:
Pyruvic acid-13C

[Synonym ]:
2-Oxopropionic acid-1-13C
|A-Ketopropionic acid-1-13C
Pyruvic-1-13C acid (free acid)
Pyruvic acid-1-13C
13C Labeled pyruvic acid
PYRUVIC-1-13C ACID (FREE ACID)

Biological Activity

[Description]:

Pyruvic acid-13C is the 13C labeled Pyruvic acid[1]. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Kładna A, et al. Reactivity of pyruvic acid and its derivatives towards reactive oxygen species. Luminescence. 2015 Nov;30(7):1153-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₄O₃

[ Molecular Weight ]:
89.05470

[ Exact Mass ]:
89.01940

[ PSA ]:
54.37000

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ RIDADR ]:
UN 3265 8 / PGII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Using [1-(13) C]lactic acid for hyperpolarized (13) C MR cardiac studies.

Magn. Reson. Med. , doi:10.1002/mrm.2535, (2014)

Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]...

Enhancing the [13C]bicarbonate signal in cardiac hyperpolarized [1-13C]pyruvate MRS studies by infusion of glucose, insulin and potassium.

NMR Biomed. 26(11) , 1496-500, (2013)

A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, ...