Tetramethylthiuram sulfide

Modify Date: 2024-01-02 09:41:14

Tetramethylthiuram sulfide Structure
Tetramethylthiuram sulfide structure
Common Name Tetramethylthiuram sulfide
CAS Number 97-74-5 Molecular Weight 208.368
Density 1.3±0.1 g/cm3 Boiling Point 260.9±23.0 °C at 760 mmHg
Molecular Formula C6H12N2S3 Melting Point 107-111 °C(lit.)
MSDS Chinese USA Flash Point 111.6±22.6 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of Tetramethylthiuram sulfide


Tetramethylthiuram monosulfide (TMTM) is an active compound. Tetramethylthiuram monosulfide (TMTM) can be used for the research of rubber and various biochemical studies[1][2].

 Names

Name Bis(Dimethylthiocarbamoyl) Sulfide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 260.9±23.0 °C at 760 mmHg
Melting Point 107-111 °C(lit.)
Molecular Formula C6H12N2S3
Molecular Weight 208.368
Flash Point 111.6±22.6 °C
Exact Mass 208.016251
PSA 95.96000
LogP 0.87
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.641
Water Solubility insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WQ1750000
CHEMICAL NAME :
Sulfide, bis(dimethylthiocarbamoyl)
CAS REGISTRY NUMBER :
97-74-5
BEILSTEIN REFERENCE NO. :
1775650
LAST UPDATED :
199806
DATA ITEMS CITED :
21
MOLECULAR FORMULA :
C6-H12-N2-S3
MOLECULAR WEIGHT :
208.38
WISWESSER LINE NOTATION :
1N1&YUS&SYUS&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
383 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
818 mg/kg
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in cell count (unspecified)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
520 mg/kg/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 nmol/L
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80220 No. of Facilities: 376 (estimated) No. of Industries: 7 No. of Occupations: 23 No. of Employees: 6032 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80220 No. of Facilities: 803 (estimated) No. of Industries: 18 No. of Occupations: 31 No. of Employees: 40683 (estimated) No. of Female Employees: 5320 (estimated)

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H317-H411
Precautionary Statements P273-P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R43;R51/53
Safety Phrases S24-S26-S37-S61
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS WQ1750000
Packaging Group III
Hazard Class 9
HS Code 3812100000

 Synthetic Route

 Customs

HS Code 3812100000

 Articles12

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 Synonyms

Tetramethylthiuram sulfide
Trithiodicarbonic diamide, N,N,N',N'-tetramethyl-
Sulfide, bis[(dimethylamino)thioxomethyl]
EINECS 202-605-7
N,N,N',N'-Tetramethyldicarbonotrithioic diamide
Bis(dimethylthiocarbamyl) sulfide
MFCD00014870
Bis(dimethylthiocarbamyl) monosulfide
TMTM
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