cyproheptadine hydrochloride

Modify Date: 2025-08-20 12:06:03

cyproheptadine hydrochloride structure	Common Name	cyproheptadine hydrochloride
	CAS Number	969-33-5	Molecular Weight	323.859
	Density	N/A	Boiling Point	440.1ºC at 760mmHg
	Molecular Formula	C₂₁H₂₂ClN	Melting Point	N/A
	MSDS	Chinese	Flash Point	194.5ºC

Use of cyproheptadine hydrochloride

Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. Target: 5-HT2 ReceptorCyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2].

Name	cyproheptadine hydrochloride (anhydrous)
Synonym	More Synonyms

Description	Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. Target: 5-HT2 ReceptorCyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9. [2]. Calka, O., et al., Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

References

[1]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9.

[2]. Calka, O., et al., Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8.

Boiling Point	440.1ºC at 760mmHg
Molecular Formula	C₂₁H₂₂ClN
Molecular Weight	323.859
Flash Point	194.5ºC
Exact Mass	323.144073
PSA	3.24000
LogP	5.43780
Storage condition	Store at RT
Water Solubility	ethanol: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7050000

CHEMICAL NAME :: Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 969-33-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C21-H21-N.Cl-H

MOLECULAR WEIGHT :: 323.89

WISWESSER LINE NOTATION :: L C676 BYJ BU- DT6N DYTJ A1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7 mg/kg/4W-C

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - jaundice, cholestatic Liver - liver function tests impaired

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 295 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 69 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 216 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 5-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - homeostasis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - endocrine system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2200 umol/L/24H (Continuous)

REFERENCE :: ZEKIA5 Zeitschrift fuer Kinderheilkunde. (Berlin, Ger.) V.1-120, 1910-75. For publisher information, see EJPEDT. Volume(issue)/page/year: 118,219,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3187 No. of Facilities: 79 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2047 (estimated) No. of Female Employees: 947 (estimated)

Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	26-36
RIDADR	UN 2811
WGK Germany	3
RTECS	TM7050000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride

Piperidine, 4- (5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride

periactinolhydrochloride

cyproheptadienehydrochloride

4-(5H-Dibenzo[a,d][7]annulen-5-yliden)-1-methylpiperidinhydrochlorid

4-(5H-dibenzo[a,d][7]annulén-5-ylidène)-1-méthylpipéridine chlorhydrate

piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride

CYPROHEPTADINE HCL BP

peritol

ANAREXOL

Cyproheptadin

Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride (1:1)

periactinhydrochloride

MFCD00012538

cyproheptadine hydrochloride

CYPROHEPTADINE HCL

EINECS 213-535-1

Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride (1:1)

periactinsyrup

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (1:1)

nuran

1-Methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine hydrochloride

1-Methyl-4-(5H-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride

Cyproheptadine (hydrochloride)

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Product Name: cyproheptadine hydrochloride
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Purity: 98.0%
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China
Product Name: Cyproheptadine hydrochloride
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Purity: 98.0%
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