RPH-2823

Modify Date: 2025-08-25 19:13:42

Use of RPH-2823

RPH-2823 is a basic triamterene derivative, with diuretic activity.

Name	RPH-2823
Synonym	More Synonyms

Description	RPH-2823 is a basic triamterene derivative, with diuretic activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vitro	RPH 2823 induces a dose-dependent decrease in SCC and increase in transepithelial electrical resistance. RPH 2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1].
In Vivo	RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].
References	[1]. Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986 Aug 15;64(16):750-9. [2]. Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-91.

Density	1.4±0.1 g/cm3
Boiling Point	690.8±65.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₂N₈O₂
Molecular Weight	370.409
Flash Point	371.6±34.3 °C
Exact Mass	370.186584
LogP	0.47
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.720
InChIKey	DREYSFUKNSYCCL-UHFFFAOYSA-N
SMILES	CN(C)CC(O)COc1ccc(-c2nc3c(N)nc(N)nc3nc2N)cc1
Storage condition	2-8℃

1-(Dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-2-propanol

2-Propanol, 1-(dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-

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Price: $360/1mg

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