RPH-2823

Names

[ Name ]:
RPH-2823

[Synonym ]:
1-(Dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-2-propanol
2-Propanol, 1-(dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-

Biological Activity

[Description]:

RPH-2823 is a basic triamterene derivative, with diuretic activity.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vitro]

RPH 2823 induces a dose-dependent decrease in SCC and increase in transepithelial electrical resistance. RPH 2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1].

[In Vivo]

RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].

[References]

[1]. Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986 Aug 15;64(16):750-9.

[2]. Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-91.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
690.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₂N₈O₂

[ Molecular Weight ]:
370.409

[ Flash Point ]:
371.6±34.3 °C

[ Exact Mass ]:
370.186584

[ LogP ]:
0.47

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.720

[ Storage condition ]:
2-8℃

Related Compounds

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