96558-24-6

96558-24-6 structure

Name	RPH-2823
Synonyms	1-(Dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-2-propanol 2-Propanol, 1-(dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-

Description	RPH-2823 is a basic triamterene derivative, with diuretic activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vitro	RPH 2823 induces a dose-dependent decrease in SCC and increase in transepithelial electrical resistance. RPH 2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1].
In Vivo	RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].
References	[1]. Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986 Aug 15;64(16):750-9. [2]. Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-91.