Irindalone
Modify Date: 2024-01-14 19:19:06
Irindalone structure
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Common Name | Irindalone | ||
|---|---|---|---|---|
| CAS Number | 96478-43-2 | Molecular Weight | 408.51200 | |
| Density | 1.219g/cm3 | Boiling Point | 605.7ºC at 760mmHg | |
| Molecular Formula | C24H29FN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 320.1ºC | |
Use of IrindaloneIrindalone is a novel serotonin 5-HT2 antagonist. |
| Name | 1-[2-[4-[(1R,3S)-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethyl]imidazolidin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Irindalone is a novel serotonin 5-HT2 antagonist. |
|---|---|
| Related Catalog | |
| Target |
5-HT2[1] |
| In Vitro | Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1]. |
| In Vivo | Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1]. |
| References |
| Density | 1.219g/cm3 |
|---|---|
| Boiling Point | 605.7ºC at 760mmHg |
| Molecular Formula | C24H29FN4O |
| Molecular Weight | 408.51200 |
| Flash Point | 320.1ºC |
| Exact Mass | 408.23300 |
| PSA | 38.82000 |
| LogP | 3.18770 |
| Index of Refraction | 1.6 |
| Storage condition | 2-8℃ |
![trans-1-[3-(4-fluorophenyl)indan-1-yl]piperazine structure](https://www.chemsrc.com/caspic/498/104887-11-8.png)
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| Irindalona |
| Irindalone |
| Irindalonum |
| UNII-4F39T8N10K |