Irindalone

Names

[ CAS No. ]:
96478-43-2

[ Name ]:
Irindalone

[Synonym ]:
Irindalona
Irindalone
Irindalonum
UNII-4F39T8N10K

Biological Activity

[Description]:

Irindalone is a novel serotonin 5-HT2 antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

[Target]

5-HT2[1]

[In Vitro]

Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT2 receptors and about a 10 times lower affinity for α1-adrenoceptors[1].

[In Vivo]

Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs[1].

[References]

[1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.219g/cm3

[ Boiling Point ]:
605.7ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₂₉FN₄O

[ Molecular Weight ]:
408.51200

[ Flash Point ]:
320.1ºC

[ Exact Mass ]:
408.23300

[ PSA ]:
38.82000

[ LogP ]:
3.18770

[ Index of Refraction ]:
1.6

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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