Isoliquiritigenin

Modify Date: 2024-01-02 12:50:29

Isoliquiritigenin structure	Common Name	Isoliquiritigenin
	CAS Number	961-29-5	Molecular Weight	256.253
	Density	1.4±0.1 g/cm3	Boiling Point	504.0±42.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₄	Melting Point	206-210°C
	MSDS	Chinese USA	Flash Point	272.7±24.4 °C

Use of Isoliquiritigenin

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM.

Name	isoliquiritigenin
Synonym	More Synonyms

Description	Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Natural Products >> Flavonoids
Target	IC50: 320 nM (Aldose reductase)
In Vitro	Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM[1]. Isoliquiritigenin (100 μM) markedly inhibits the hypoxia-induced prolonged TPS and TR90 of cardiomyocytes. Isoliquiritigenin significantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenin treatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes. Isoliquiritigenin treatment significantly decreases the intracellular ROS levels of isolated cardiomyocytes during hypoxia/reoxygenation[3]. Isoliquiritigenin not only downregulates IL-6 expression but also significantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6, which are critical signaling proteins in IL-6 signaling regulation networks[4].
In Vivo	Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum induced by various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC50 values of 4.96±1.97 mM, 4.03±1.34 mM and 3.70±0.58 mM, respectively[2]. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin[4].
References	[1]. Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. [2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. [3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. [4]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.

Density	1.4±0.1 g/cm3
Boiling Point	504.0±42.0 °C at 760 mmHg
Melting Point	206-210°C
Molecular Formula	C₁₅H₁₂O₄
Molecular Weight	256.253
Flash Point	272.7±24.4 °C
Exact Mass	256.073547
PSA	77.76000
LogP	3.11
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.715
Storage condition	2-8°C
Water Solubility	H2O: <0.1 mg/mL

Isoliquiritigenin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL7080000

CHEMICAL NAME :: Chalcone, 2',4,4'-trihydroxy-

CAS REGISTRY NUMBER :: 961-29-5

LAST UPDATED :: 199606

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-O4

MOLECULAR WEIGHT :: 256.27

WISWESSER LINE NOTATION :: QR CQ DV1U1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	FL7080000
HS Code	2914501900

Precursor 6
CAS#:89-84-9 2,4-Dihydroxyac... CAS#:123-08-0 4-hydroxybenzal... CAS#:74189-56-3 4-(2-NAPHTHYLOX... CAS#:6515-21-5 4-(methoxymetho...
CAS#:6515-05-5 1-(2,4-bis(meth... CAS#:100-52-7 Benzaldehyde
DownStream 10
CAS#:578-86-9 Liquiritigenin CAS#:14796-48-6 6-hydroxy-2-[hy... CAS#:89-86-1 2,4-Dihydroxybe... CAS#:2034-65-3 3,7,4'-trihydro...
CAS#:111915-65-2 trans-3,4',7-tr... CAS#:61443-82-1 (2,4-dihydroxy-... CAS#:85359-61-1 chalaurenol CAS#:89-84-9 2,4-Dihydroxyac...
CAS#:64687-96-3 5-hydroxy-2-(4-... CAS#:123-08-0 4-hydroxybenzal...

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.

Chem. Biol. Interact. 225 , 13-20, (2015)

Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury in...

Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis.

Biosci. Biotechnol. Biochem. 79 , 799-807, (2015)

Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobact...

Flavonoids and Auxin Transport Inhibitors Rescue Symbiotic Nodulation in the Medicago truncatula Cytokinin Perception Mutant cre1.

Plant Cell 27 , 2210-26, (2015)

Initiation of symbiotic nodules in legumes requires cytokinin signaling, but its mechanism of action is largely unknown. Here, we tested whether the failure to initiate nodules in the Medicago truncat...

iso-Liquiritigenin

Isoliquiritigenin

QR CQ DV1U1R DQ &&E Form

ISL

(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

gu17

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-

MFCD00075907

(2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

ISOLIQUIRTIGENIN

4,2',4'-TRIHYDROXYCHALCONE

Isqliquiritigenin

2',4',4-TRIHYDROXYCHALCONE

(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

2',4,4'-Trihydroxychalcone

BioBioPha
China
Product Name: Isoliquiritigenin
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isoliquiritigenin
Price: ￥568.0/1g ￥258.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Isoliquiritigenin
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
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Zhejiang Hangyu API Co., Ltd
China
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Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFUCHEM--961-29-5--Isoliquiritigenin
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Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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