(+)-guajadial

Modify Date: 2025-08-27 16:16:53

(+)-guajadial Structure
(+)-guajadial structure
Common Name (+)-guajadial
CAS Number 959860-49-2 Molecular Weight 474.59
Density 1.3±0.1 g/cm3 Boiling Point 518.7±50.0 °C at 760 mmHg
Molecular Formula C30H34O5 Melting Point N/A
MSDS N/A Flash Point 160.7±23.6 °C

 Use of (+)-guajadial


Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].

 Names

Name (2aR,4aR,10R,10aS,13aS)-7,9-Dihydroxy-2,2,4a-trimethyl-13-methyle ne-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobu ta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde
Synonym More Synonyms

 (+)-guajadial Biological Activity

Description Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].
Related Catalog
References

[1]. Bazioli JM, et al. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.). Molecules. 2020 Mar 27;25(7):1525.  

[2]. Li Y, et al. Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells. Chem Biol Interact. 2019 May 25;305:98-104.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 518.7±50.0 °C at 760 mmHg
Molecular Formula C30H34O5
Molecular Weight 474.59
Flash Point 160.7±23.6 °C
Exact Mass 474.240631
PSA 83.83000
LogP 10.34
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.627

 Safety Information

Hazard Codes Xi

 Synonyms

(2aR,4aR,10R,10aS,13aS)-7,9-Dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobuta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde
Benzo[b]cyclobuta[5,6]cyclonona[1,2-e]pyran-6,8-dicarboxaldehyde, 1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydro-7,9-dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-, (2aR,4aR,10R,10aS,13aS)-
guajadial
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