959860-49-2

959860-49-2 structure

Name: (+)-guajadial
Chemical Name: (2aR,4aR,10R,10aS,13aS)-7,9-Dihydroxy-2,2,4a-trimethyl-13-methyle ne-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobu ta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde
CAS Number: 959860-49-2
Molecular Formula: C₃₀H₃₄O₅
Molecular Weight: 474.59
Catalog: Natural product Sesquiter
Create Date: 2017-10-28 09:03:40
Modify Date: 2025-08-27 16:16:53
Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].

Name	(2aR,4aR,10R,10aS,13aS)-7,9-Dihydroxy-2,2,4a-trimethyl-13-methyle ne-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobu ta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde
Synonyms	(2aR,4aR,10R,10aS,13aS)-7,9-Dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobuta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde Benzo[b]cyclobuta[5,6]cyclonona[1,2-e]pyran-6,8-dicarboxaldehyde, 1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydro-7,9-dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-, (2aR,4aR,10R,10aS,13aS)- guajadial

Description	Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Bazioli JM, et al. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.). Molecules. 2020 Mar 27;25(7):1525. [2]. Li Y, et al. Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells. Chem Biol Interact. 2019 May 25;305:98-104.

Hazard Codes	Xi