SLC26A3-IN-2
Modify Date: 2025-08-25 19:31:32
SLC26A3-IN-2 structure
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Common Name | SLC26A3-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 950348-60-4 | Molecular Weight | 368.84 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H13ClN2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SLC26A3-IN-2SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1]. |
| Name | SLC26A3-IN-2 |
|---|
| Description | SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1]. |
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| Related Catalog | |
| In Vitro | SLC26A3-IN-2 (化合物3a) (10 μM; 10 min) 对 SLC26A3 的抑制率为 92%[1]。 |
| In Vivo | SLC26A3-IN-2 (10 mg/kg；口服) 在 Loperamide (HY-B0418A) 诱导的小鼠便秘模型中显著增加粪便重量和颗粒数量，证明其增加小鼠粪便水化的功效[1]。 |
| References |
| Molecular Formula | C19H13ClN2O2S |
|---|---|
| Molecular Weight | 368.84 |