950348-60-4

950348-60-4 structure

Name: SLC26A3-IN-2
Chemical Name: SLC26A3-IN-2
CAS Number: 950348-60-4
Molecular Formula: C₁₉H₁₃ClN₂O₂S
Molecular Weight: 368.84
Catalog: Research Areas Metabolic Disease
Create Date: 2023-06-27 12:04:10
Modify Date: 2025-08-25 19:31:32
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].

Name	SLC26A3-IN-2

Description	SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	SLC26A3-IN-2 (化合物3a) (10 μM; 10 min) 对 SLC26A3 的抑制率为 92%[1]。
In Vivo	SLC26A3-IN-2 (10 mg/kg；口服) 在 Loperamide (HY-B0418A) 诱导的小鼠便秘模型中显著增加粪便重量和颗粒数量，证明其增加小鼠粪便水化的功效[1]。
References	[1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.

Molecular Formula	C₁₉H₁₃ClN₂O₂S
Molecular Weight	368.84