SLC26A3-IN-2

Names

[ Name ]:
SLC26A3-IN-2

Biological Activity

[Description]:

SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

SLC26A3-IN-2 (化合物3a) (10 μM; 10 min) 对 SLC26A3 的抑制率为 92%[1]。

[In Vivo]

SLC26A3-IN-2 (10 mg/kg；口服) 在 Loperamide (HY-B0418A) 诱导的小鼠便秘模型中显著增加粪便重量和颗粒数量，证明其增加小鼠粪便水化的功效[1]。

[References]

[1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₃ClN₂O₂S

[ Molecular Weight ]:
368.84

Related Compounds

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