salicylaldehyde, oxime

Modify Date: 2025-08-22 15:19:56

salicylaldehyde, oxime Structure
salicylaldehyde, oxime structure
 Common Name salicylaldehyde, oxime
CAS Number 94-67-7 Molecular Weight 137.136
Density 1.2±0.1 g/cm3 Boiling Point 256.5±23.0 °C at 760 mmHg
Molecular Formula C7H7NO2 Melting Point 59-61 °C(lit.)
MSDS Chinese USA Flash Point 146.9±11.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of salicylaldehyde, oxime


Salicylaldoxime is an organic compound, that has been used as a reagent for the gravimetric determination and separation of Cooper, Nickel, Palladium, Lead, Bismuth and Zine. The copper complex of Salicylaldoxime has anticancer activity[1][2].

 Names

Name Salicylaldoxime
Synonym More Synonyms

 salicylaldehyde, oxime Biological Activity

Description Salicylaldoxime is an organic compound, that has been used as a reagent for the gravimetric determination and separation of Cooper, Nickel, Palladium, Lead, Bismuth and Zine. The copper complex of Salicylaldoxime has anticancer activity[1][2].
Related Catalog
In Vitro Salicylaldoxime (300 μM) completely inhibits the relaxation activity of topoisomerase II when it forms a complex with copper; also inhibits L1210 leukaemia cell proliferation[1].
References

[1]. W Ligett and L Biefeld. Separation and Determination of Lead with Salicylaldoxime. Ind. Eng. Chem. Anal. Ed. 1941, 13, 11, 813-815.

[2]. D. Jayaraju and Anand K. Kondapi. Anti-cancer copper salicylaldoxime complex inhibits topoisomerase II catalytic activity. Current Science. Vol. 81, No. 7 (10 October 2001), pp. 787-792

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 256.5±23.0 °C at 760 mmHg
Melting Point 59-61 °C(lit.)
Molecular Formula C7H7NO2
Molecular Weight 137.136
Flash Point 146.9±11.9 °C
Exact Mass 137.047684
PSA 52.82000
LogP 1.88
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.552
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VN5775000
CHEMICAL NAME :
Salicylaldehyde, oxime
CAS REGISTRY NUMBER :
94-67-7
BEILSTEIN REFERENCE NO. :
1859881
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H7-N-O2
MOLECULAR WEIGHT :
137.15
WISWESSER LINE NOTATION :
QNU1R BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,36,1953

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS VN5775000

 Synthetic Route

 Articles26

More Articles
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

Eur. J. Med. Chem. 46 , 2453-62, (2011)

In a continuing effort to improve the subtype selectivity and agonist potency of estrogen receptor β (ERβ) ligands, we have designed and developed a thus far unexplored structural series obtained by m...

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta.

J. Med. Chem. 52 , 858-67, (2009)

The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class ...

Linking [M(III)3] triangles with "double-headed" phenolic oximes.

Dalton Trans. 41(29) , 8777-85, (2012)

Strapping two salicylaldoxime units together with aliphatic α,Ω-aminomethyl links in the 3-position gives ligands which allow the assembly of the polynuclear complexes [Fe(7)O(2)(OH)(6)(H(2)L1)(3)(py)...

 Synonyms

2-hydroxybenzaldehyde oxime
salicylaldehyde, oxime
Saldox
Benzaldehyde, 2-hydroxy-, oxime
SALICYLALDEHYDE OXIME
Salicylaldehydoxime
2-hydroxybenzaldoxime
SalicyladoximeGr
o-Hydroxybenzaldoxime
MFCD00002120
o-hydroxybenzaldehyde oxime
EINECS 202-353-8
2-[(Hydroxyimino)methyl]phenol
Salicaldehyde oxime
2-[(E)-(Hydroxyimino)methyl]phenol
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