MK-4101
Modify Date: 2025-08-20 17:48:13
MK-4101 structure
|
Common Name | MK-4101 | ||
|---|---|---|---|---|
| CAS Number | 935273-79-3 | Molecular Weight | 493.472 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 606.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H24F5N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 320.4±34.3 °C | |
Use of MK-4101MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.target:SMOIn vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice.In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors. |
| Name | 5-(3,3-Difluorocyclobutyl)-3-(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)-1,2,4-oxadiazole |
|---|---|
| Synonym | More Synonyms |
| Description | MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.target:SMOIn vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice.In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 606.1±65.0 °C at 760 mmHg |
| Molecular Formula | C24H24F5N5O |
| Molecular Weight | 493.472 |
| Flash Point | 320.4±34.3 °C |
| Exact Mass | 493.190094 |
| LogP | 4.58 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.654 |
| InChIKey | HKJOIWLYDJCTQR-UHFFFAOYSA-N |
| SMILES | Cn1c(-c2ccccc2C(F)(F)F)nnc1C12CCC(c3noc(C4CC(F)(F)C4)n3)(CC1)CC2 |
| Storage condition | -20℃ |
| 5-(3,3-Difluorocyclobutyl)-3-(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)-1,2,4-oxadiazole |
| 1,2,4-Oxadiazole, 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]- |
| MK-4101 |