MK-608

Modify Date: 2024-01-02 14:58:58

MK-608 structure	Common Name	MK-608
	CAS Number	443642-29-3	Molecular Weight	280.280
	Density	1.8±0.1 g/cm3	Boiling Point	620.7±55.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₆N₄O₄	Melting Point	222 °C(Solv: methanol (67-56-1)
	MSDS	N/A	Flash Point	329.2±31.5 °C

Use of MK-608

MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay[1].

Name	(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Synonym	More Synonyms

Description	MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	EC50: 0.3 μM (HCV replication)[1]
In Vivo	Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively)[1]. Animal Model: The HCV-infected chimpanzees[1] Dosage: 1 mg/kg Administration: Administered orally; once daily for 37 days Result: Chimpanzee X6 had a baseline viral load that varied from 1,110 to 12,900 IU/mL, and chimpanzee X4 had a baseline viral load of 3×106 to 9×106 IU/mL.
References	[1]. Carroll SS, et al. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob Agents Chemother. 2009 Mar;53(3):926-34.

Density	1.8±0.1 g/cm3
Boiling Point	620.7±55.0 °C at 760 mmHg
Melting Point	222 °C(Solv: methanol (67-56-1)
Molecular Formula	C₁₂H₁₆N₄O₄
Molecular Weight	280.280
Flash Point	329.2±31.5 °C
Exact Mass	280.117157
PSA	126.65000
LogP	0.22
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.769
Storage condition	2-8°C

MK-608

Lamevudine

(2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol

7-deaza-2’-C-methyladenosine

7-Deaza-2'-C-methyladenosine

7DMA

7-(2-C-Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-methyl-β-D-ribofuranosyl)-

DC Chemicals Limited
China
Product Name: MK-0608
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2R,3R,4R,5R)-2-(4-AMINO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-3-METHYLTETRAHYDROFURAN-3,4-DIOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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MK-608

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