BG-45
Modify Date: 2025-08-20 16:41:23
BG-45 structure
|
Common Name | BG-45 | ||
|---|---|---|---|---|
| CAS Number | 926259-99-6 | Molecular Weight | 214.223 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 319.0±32.0 °C at 760 mmHg | |
| Molecular Formula | C11H10N4O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 146.7±25.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BG-45BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1 |
| Name | N-(2-Aminophenyl)pyrazine-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1 |
|---|---|
| Related Catalog | |
| Target |
HDAC3:0.289 μM (IC50) HDAC1:2.0 μM (IC50) HDAC2:2.2 μM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 319.0±32.0 °C at 760 mmHg |
| Molecular Formula | C11H10N4O |
| Molecular Weight | 214.223 |
| Flash Point | 146.7±25.1 °C |
| Exact Mass | 214.085464 |
| LogP | 0.18 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.708 |
| InChIKey | LMWPVSNHKACEKW-UHFFFAOYSA-N |
| SMILES | Nc1ccccc1NC(=O)c1cnccn1 |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| N-(2-Aminophenyl)-2-pyrazinecarboxamide |
| 2-Pyrazinecarboxamide, N-(2-aminophenyl)- |
| BG-45 |
| BG45 |