BG-45

Modify Date: 2025-08-20 16:41:23

BG-45 structure	Common Name	BG-45
	CAS Number	926259-99-6	Molecular Weight	214.223
	Density	1.4±0.1 g/cm3	Boiling Point	319.0±32.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₀N₄O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	146.7±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of BG-45

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1

Name	N-(2-Aminophenyl)pyrazine-2-carboxamide
Synonym	More Synonyms

Description	BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1
Related Catalog	Research Areas >> Cancer
Target	HDAC3:0.289 μM (IC50) HDAC1:2.0 μM (IC50) HDAC2:2.2 μM (IC50)
References	[1]. Iaconelli J, et al. HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells. ACS Chemical Biology (2015), 10(3), 883-890. [2]. Tang D, et al. Metformin facilitates BG45-induced apoptosis via an anti-Warburg effect in cholangiocarcinoma cells. Oncol Rep. 2018 Apr;39(4):1957-1965.

Density	1.4±0.1 g/cm3
Boiling Point	319.0±32.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₀N₄O
Molecular Weight	214.223
Flash Point	146.7±25.1 °C
Exact Mass	214.085464
LogP	0.18
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.708
Storage condition	-20℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport

N-(2-Aminophenyl)-2-pyrazinecarboxamide

2-Pyrazinecarboxamide, N-(2-aminophenyl)-

BG-45

BG45

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China
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China
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DC Chemicals Limited
China
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Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: BG-45
Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/1mg
Purity: 99.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 406104890@qq.com

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Price: $79/10mM*1mLinDMSO

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BG-45

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.