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BG-45

Names

[ CAS No. ]:
926259-99-6

[ Name ]:
BG-45

[Synonym ]:
N-(2-Aminophenyl)-2-pyrazinecarboxamide
2-Pyrazinecarboxamide, N-(2-aminophenyl)-
BG-45
BG45

Biological Activity

[Description]:

BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC3:0.289 μM (IC50)

HDAC1:2.0 μM (IC50)

HDAC2:2.2 μM (IC50)


[References]

[1]. Iaconelli J, et al. HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells. ACS Chemical Biology (2015), 10(3), 883-890.

[2]. Tang D, et al. Metformin facilitates BG45-induced apoptosis via an anti-Warburg effect in cholangiocarcinoma cells. Oncol Rep. 2018 Apr;39(4):1957-1965.


[Related Small Molecules]

Trichostatin A | Entinostat (MS-275) | Romidepsin (FK228, Depsipeptide) | Mocetinostat(MGCD0103) | Ricolinostat (ACY-1215) | Sodium butyrate | RGFP 966 | Quisinostat | Tubacin | DL-Sulforaphane | CUDC-907 | LMK 235 | CI-994 | Tubastatin A | Sodium phenylbutyrate

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
319.0±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H10N4O

[ Molecular Weight ]:
214.223

[ Flash Point ]:
146.7±25.1 °C

[ Exact Mass ]:
214.085464

[ LogP ]:
0.18

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.708

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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