926259-99-6

926259-99-6 structure

Name: BG-45
Chemical Name: N-(2-Aminophenyl)pyrazine-2-carboxamide
CAS Number: 926259-99-6
Molecular Formula: C₁₁H₁₀N₄O
Molecular Weight: 214.223
Catalog: Research Areas Cancer
Create Date: 2017-02-12 04:58:07
Modify Date: 2025-08-20 16:41:23
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1

Name	N-(2-Aminophenyl)pyrazine-2-carboxamide
Synonyms	N-(2-Aminophenyl)-2-pyrazinecarboxamide 2-Pyrazinecarboxamide, N-(2-aminophenyl)- BG-45 BG45

Description	BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).IC50 value: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)Target: HDACAt concentrations up to 50 mg/kg, BG45 alone or in combination with Bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.1
Related Catalog	Research Areas >> Cancer
Target	HDAC3:0.289 μM (IC50) HDAC1:2.0 μM (IC50) HDAC2:2.2 μM (IC50)
References	[1]. Iaconelli J, et al. HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells. ACS Chemical Biology (2015), 10(3), 883-890. [2]. Tang D, et al. Metformin facilitates BG45-induced apoptosis via an anti-Warburg effect in cholangiocarcinoma cells. Oncol Rep. 2018 Apr;39(4):1957-1965.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport