Toluidine Blue

Modify Date: 2024-01-02 16:52:37

Toluidine Blue structure	Common Name	Toluidine Blue
	CAS Number	92-31-9	Molecular Weight	305.826
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₆ClN₃S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Toluidine Blue

Toluidine Blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain[1].

Name	tolonium chloride
Synonym	More Synonyms

Description	Toluidine Blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Sridharan G, et al. Toluidine blue: A review of its chemistry and clinical utility. J Oral Maxillofac Pathol. 2012;16(2):251-255.

Molecular Formula	C₁₅H₁₆ClN₃S
Molecular Weight	305.826
Exact Mass	305.075348
PSA	70.39000
LogP	1.27240

Toluidine Blue MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5670000

CHEMICAL NAME :: Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride

CAS REGISTRY NUMBER :: 92-31-9

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C15-H16-N3-S.Cl

MOLECULAR WEIGHT :: 305.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 43 mg/kg/6D

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28930 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27560 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 13440 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1164 No. of Facilities: 224 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1226 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1164 No. of Facilities: 196 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 7956 (estimated) No. of Female Employees: 5824 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F+
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SP5670000
HS Code	32041300

o-Toluidine HCl

CAS#:636-21-5

p-Dimethylamino...

CAS#:536-46-9

N/A

CAS#:225091-67-8

N/A

CAS#:225091-65-6

Detail

Literature: WO2003/103569 A2, ; Page 17-19 ;

Precursor 2
CAS#:636-21-5 o-Toluidine HCl CAS#:536-46-9 p-Dimethylamino...
DownStream 0

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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The canine epiphyseal-derived mesenchymal stem cells are comparable to bone marrow derived-mesenchymal stem cells.

J. Vet. Med. Sci. 77(3) , 273-80, (2015)

Mesenchymal stem cells (MSCs) hold great potential in cell therapy and have attracted increasing interests in a wide range of biomedical sciences. However, the scarcity of MSCs and the prolonged isola...

Analysis and testing of biological stains--the Biological Stain Commission Procedures.

Biotech. Histochem. 77(5&6) , 237-275, (2002)

Methanaminium, N-(7-amino-8-methyl-3H-phenothiazin-3-ylidene)-N-methyl-, chloride (1:1)

PHENOTHIAZIN-5-IUM, 3-AMINO-7-(DIMETHYLAMINO)-2-METHYL-, CHLORIDE

Toluidine Blue O, pure

3-Amino-7-dimethylamino-2-methylphenazathionium Chloride

3-Amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride

Phenothiazinium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1)

EINECS 202-146-2

(7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium,chloride

3-Amino-7-(dimethylamino)-2-methylphenothiazinium chloride

Phenothiazinium, 3-amino-7-(dimethylamino)-2-methyl-, chloride

MFCD00011934

T C666 BN ISJ E1 FZ LN1&1 &&Chloride

Tolonium chloride (C.I. 52040)

7-Amino-N,N,8-trimethyl-3H-phenothiazin-3-iminium chloride

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Toluidine Blue
Price: ￥158.0/5g ￥538.0/25g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Toluidine Blue
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Basic Blue 17
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Toluidine Blue

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Toluidine Blue Biological Activity

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