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92-31-9

92-31-9 structure
92-31-9 structure
  • Name: Toluidine Blue
  • Chemical Name: tolonium chloride
  • CAS Number: 92-31-9
  • Molecular Formula: C15H16ClN3S
  • Molecular Weight: 305.826
  • Catalog: Dyes and pigments dye Basic dye
  • Create Date: 2018-02-10 08:00:00
  • Modify Date: 2025-08-20 23:01:08
  • Toluidine Blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain[1].
Name tolonium chloride
Synonyms Methanaminium, N-(7-amino-8-methyl-3H-phenothiazin-3-ylidene)-N-methyl-, chloride (1:1)
PHENOTHIAZIN-5-IUM, 3-AMINO-7-(DIMETHYLAMINO)-2-METHYL-, CHLORIDE
Toluidine Blue O, pure
3-Amino-7-dimethylamino-2-methylphenazathionium Chloride
3-Amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
Phenothiazinium, 3-amino-7-(dimethylamino)-2-methyl-, chloride (1:1)
EINECS 202-146-2
(7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium,chloride
3-Amino-7-(dimethylamino)-2-methylphenothiazinium chloride
Phenothiazinium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
MFCD00011934
T C666 BN ISJ E1 FZ LN1&1 &&Chloride
Tolonium chloride (C.I. 52040)
7-Amino-N,N,8-trimethyl-3H-phenothiazin-3-iminium chloride
Description Toluidine Blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain[1].
Related Catalog
References

[1]. Sridharan G, et al. Toluidine blue: A review of its chemistry and clinical utility. J Oral Maxillofac Pathol. 2012;16(2):251-255.
Molecular Formula C15H16ClN3S
Molecular Weight 305.826
Exact Mass 305.075348
PSA 70.39000
LogP 1.27240

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP5670000
CHEMICAL NAME :
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-2-methyl-, chloride
CAS REGISTRY NUMBER :
92-31-9
LAST UPDATED :
199706
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C15-H16-N3-S.Cl
MOLECULAR WEIGHT :
305.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
43 mg/kg/6D
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28930 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27560 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
13440 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1164 No. of Facilities: 224 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1226 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1164 No. of Facilities: 196 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 7956 (estimated) No. of Female Employees: 5824 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F+
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SP5670000
HS Code 32041300
636-21-5 structure

636-21-5

536-46-9 structure

536-46-9

~%

225091-67-8 structure

225091-67-8

225091-65-6 structure

225091-65-6

Detail
Literature: WO2003/103569 A2, ; Page 17-19 ;
Precursor  2

DownStream  0

HS Code 2934300000
Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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