phenyltoloxamine

Modify Date: 2025-08-27 22:12:14

phenyltoloxamine structure	Common Name	phenyltoloxamine
	CAS Number	92-12-6	Molecular Weight	255.35500
	Density	1.022g/cm3	Boiling Point	359.2ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₁NO	Melting Point	N/A
	MSDS	N/A	Flash Point	106ºC

Use of phenyltoloxamine

Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].

Name	2-(2-benzylphenoxy)-N,N-dimethylethanamine
Synonym	More Synonyms

Description	Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Sigma 1 Receptor:160 nM (Ki)
In Vitro	Phenyltoloxamine (10-50 μM, 24 h) demonstrates cytotoxicity in EVSA-T cells[2]. Phenyltoloxamine exhibits potent Sigma 1 Receptor (S1R) binding affinity with a Ki value of 160 nM[3]. Phenyltoloxamine (100 μM) inhibits human liver macrosaml CYP2D6 enzyme by 99.0%[4].

Density	1.022g/cm3
Boiling Point	359.2ºC at 760 mmHg
Molecular Formula	C₁₇H₂₁NO
Molecular Weight	255.35500
Flash Point	106ºC
Exact Mass	255.16200
PSA	12.47000
LogP	3.21780
Index of Refraction	1.552

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH2376000

CHEMICAL NAME :: Ethanamine, N,N-dimethyl-2-(2-(phenylmethyl)phenoxy)-

CAS REGISTRY NUMBER :: 92-12-6

BEILSTEIN REFERENCE NO. :: 1986598

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H21-N-O

MOLECULAR WEIGHT :: 255.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1127 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83250 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)

2-Benzylphenol

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phenyltoloxamine

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Literature: Journal of Medicinal Chemistry, , vol. 47, # 17 p. 4155 - 4158

2-benzylphenol-...

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phenyltoloxamine

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sodium o-benzyl...

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2-Chloroethyldi...

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phenyltoloxamine

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Literature: Journal of the American Chemical Society, , vol. 71, p. 60,62

Precursor 5
CAS#:28994-41-4 2-Benzylphenol CAS#:165683-42-1 2-benzylphenol-... CAS#:124-40-3 Dimethylamine CAS#:7563-58-8 sodium o-benzyl...
CAS#:107-99-3 2-Chloroethyldi...
DownStream 1
CAS#:111500-79-9 2-(2-benzylphen...

Feniltolossamina [DCIT]

Phenyltoloxamine

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[2-(2-benzyl-phenoxy)-ethyl]-dimethyl-amine

Histionex

2-Dimethylamino-1-(2-benzyl-phenoxy)-aethan

Bistrimin

Phenoxadrin

UNII-K65LB6598J

Phenyl-toloxamin

Phentoloxamine

Bristamin

[2-(2-Benzyl-phenoxy)-aethyl]-dimethyl-amin

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