CB2 receptor agonist 3

Modify Date: 2024-01-12 11:10:20

CB2 receptor agonist 3 Structure
CB2 receptor agonist 3 structure
Common Name CB2 receptor agonist 3
CAS Number 919077-81-9 Molecular Weight 440.365
Density 1.4±0.1 g/cm3 Boiling Point 632.9±55.0 °C at 760 mmHg
Molecular Formula C24H23Cl2N3O Melting Point N/A
MSDS N/A Flash Point 336.6±31.5 °C

 Use of CB2 receptor agonist 3


CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells[1].

 Names

Name N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-4H-indeno[1,2-c]pyrazole-3-carboxamide
Synonym More Synonyms

 CB2 receptor agonist 3 Biological Activity

Description CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells[1].
Related Catalog
In Vitro CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells[1].
References

[1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 632.9±55.0 °C at 760 mmHg
Molecular Formula C24H23Cl2N3O
Molecular Weight 440.365
Flash Point 336.6±31.5 °C
Exact Mass 439.121826
PSA 46.92000
LogP 6.58
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.700

 Synonyms

nor-Binaltorphimine dihydrochloride
HMS3269N05
N-Cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide
GP 2A
Indeno[1,2-c]pyrazole-3-carboxamide, N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl-
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