919077-81-9

919077-81-9 structure

Name: CB2 receptor agonist 3
Chemical Name: N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-4H-indeno[1,2-c]pyrazole-3-carboxamide
CAS Number: 919077-81-9
Molecular Formula: C₂₄H₂₃Cl₂N₃O
Molecular Weight: 440.365
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2017-01-27 01:22:21
Modify Date: 2025-08-23 10:03:04
CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells[1].

Name	N-cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-4H-indeno[1,2-c]pyrazole-3-carboxamide
Synonyms	nor-Binaltorphimine dihydrochloride HMS3269N05 N-Cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide GP 2A Indeno[1,2-c]pyrazole-3-carboxamide, N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl-

Description	CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
In Vitro	CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells[1].
References	[1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.