demeton-S-methyl

Modify Date: 2024-01-07 19:05:32

demeton-S-methyl Structure
demeton-S-methyl structure
Common Name demeton-S-methyl
CAS Number 919-86-8 Molecular Weight 230.28500
Density 1.197g/cm3 Boiling Point 287.4ºC at 760 mmHg
Molecular Formula C6H15O3PS2 Melting Point <25℃
MSDS USA Flash Point 2ºC
Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger

 Names

Name demeton-S-methyl
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.197g/cm3
Boiling Point 287.4ºC at 760 mmHg
Melting Point <25℃
Molecular Formula C6H15O3PS2
Molecular Weight 230.28500
Flash Point 2ºC
Exact Mass 230.02000
PSA 95.94000
LogP 2.87360
Index of Refraction 1.496

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TG1750000
CHEMICAL NAME :
Phosphorothioic acid, S-(2-(ethylthio)ethyl) O,O-dimethyl ester
CAS REGISTRY NUMBER :
919-86-8
BEILSTEIN REFERENCE NO. :
1707311
LAST UPDATED :
199703
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C6-H15-O3-P-S2
MOLECULAR WEIGHT :
230.30
WISWESSER LINE NOTATION :
2S2SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
12500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
80 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 28,405,1975 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976

 Safety Information

Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger
Hazard Statements H301 + H311-H411
Precautionary Statements P273-P280-P301 + P310 + P330-P302 + P352 + P312-P391-P501
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T,N,Xn,F
Risk Phrases 24/25-51/53-36-20/21/22-11
Safety Phrases S26;S36/S37
RIDADR UN 3018
RTECS TG1750000
Packaging Group II
Hazard Class 6.1(a)

 Synthetic Route

~13%

demeton-S-methyl Structure

demeton-S-methyl

CAS#:919-86-8

Literature: Terreni, Marco; Pregnolato, Massimo; Resnati, Giuseppe; Benfenati, Emilio Tetrahedron, 1995 , vol. 51, # 29 p. 7981 - 7992

~%

demeton-S-methyl Structure

demeton-S-methyl

CAS#:919-86-8

Literature: DE947367 , ;

~%

demeton-S-methyl Structure

demeton-S-methyl

CAS#:919-86-8

Literature: Biochemical Journal, , vol. 67, p. 187,189,191 Journal of the Chemical Society, , p. 1643,1647,1649

~%

demeton-S-methyl Structure

demeton-S-methyl

CAS#:919-86-8

Literature: Zeitschrift fuer Naturforschung, , vol. 10b, p. 12,15-19

~%

demeton-S-methyl Structure

demeton-S-methyl

CAS#:919-86-8

Literature: Zeitschrift fuer Naturforschung, , vol. 10b, p. 12,15-19

 Articles25

More Articles
Mutagenesis of organophosphorus hydrolase to enhance hydrolysis of the nerve agent VX.

Biochem. Biophys. Res. Commun. 279(2) , 516-9, (2000)

Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent ...

[First drafts of the Environmental Health Criteria (EHC) circulated for comments by IPCS in 1995-1996].

Eisei Shikenjo Hokoku. (114) , 95-8, (1996)

Genes coding for cytochrome P450 are regulated by endogenous hormones such as the growth hormone, corticosteroids, thyroid, and sex hormones. Secretion of these hormones is regulated by the respective...

[The decrement-increment phenomenon in disorders of neuromuscular transmission by inhibition of acetylcholinesterase].

EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte Geb. 20(1) , 28-33, (1989)

Repetitive stimulation of the median nerve elicited a so far unknown course of the muscle action potentials in four patients with organophosphate intoxications. The amplitude of the initial muscle act...

 Synonyms

Methyl isosystox
S-[2-(ethylsulfanyl)ethyl] O,O-dimethyl phosphorothioate
Metaisosystox
DEMETON-S-METHYL
S-2-ethylthioethyl O,O-dimethyl phosphorothioate
MFCD00055464
Thiometon oxon
Demetox
Metasystox J
O,O-dimethyl S-2-ethylthioethyl phosphorothioate
methylmercaptophos thiol
Metasystox 55
1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane
EINECS 213-052-6
Metaisoseptox
S-[2-(ethylthio)ethyl] O,O-dimethyl phosphorothioate
Duratox
Methyldemetone