demeton-S-methyl
Names
[ CAS No. ]:
919-86-8
[ Name ]:
demeton-S-methyl
[Synonym ]:
Methyl isosystox
S-[2-(ethylsulfanyl)ethyl] O,O-dimethyl phosphorothioate
Metaisosystox
DEMETON-S-METHYL
S-2-ethylthioethyl O,O-dimethyl phosphorothioate
MFCD00055464
Thiometon oxon
Demetox
Metasystox J
O,O-dimethyl S-2-ethylthioethyl phosphorothioate
methylmercaptophos thiol
Metasystox 55
1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane
EINECS 213-052-6
Metaisoseptox
S-[2-(ethylthio)ethyl] O,O-dimethyl phosphorothioate
Duratox
Methyldemetone
Chemical & Physical Properties
[ Density]:
1.197g/cm3
[ Boiling Point ]:
287.4ºC at 760 mmHg
[ Melting Point ]:
<25℃
[ Molecular Formula ]:
C6H15O3PS2
[ Molecular Weight ]:
230.28500
[ Flash Point ]:
2ºC
[ Exact Mass ]:
230.02000
[ PSA ]:
95.94000
[ LogP ]:
2.87360
[ Index of Refraction ]:
1.496
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TG1750000
- CHEMICAL NAME :
- Phosphorothioic acid, S-(2-(ethylthio)ethyl) O,O-dimethyl ester
- CAS REGISTRY NUMBER :
- 919-86-8
- BEILSTEIN REFERENCE NO. :
- 1707311
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C6-H15-O3-P-S2
- MOLECULAR WEIGHT :
- 230.30
- WISWESSER LINE NOTATION :
- 2S2SPO&O1&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 85 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 80 ppm
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 28,405,1975 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976
Safety Information
[ Symbol ]:
GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311-H411
[ Precautionary Statements ]:
P273-P280-P301 + P310 + P330-P302 + P352 + P312-P391-P501
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T,N,Xn,F
[ Risk Phrases ]:
24/25-51/53-36-20/21/22-11
[ Safety Phrases ]:
S26;S36/S37
[ RIDADR ]:
UN 3018
[ RTECS ]:
TG1750000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Synthetic Route
Articles
Biochem. Biophys. Res. Commun. 279(2) , 516-9, (2000)
Organophosphorus hydrolase (OPH) is capable of hydrolyzing a wide variety of organophosphorus pesticides and chemical warfare agents. However, the hydrolytic activity of OPH against the warfare agent ...
[First drafts of the Environmental Health Criteria (EHC) circulated for comments by IPCS in 1995-1996].Eisei Shikenjo Hokoku. (114) , 95-8, (1996)
Genes coding for cytochrome P450 are regulated by endogenous hormones such as the growth hormone, corticosteroids, thyroid, and sex hormones. Secretion of these hormones is regulated by the respective...
[The decrement-increment phenomenon in disorders of neuromuscular transmission by inhibition of acetylcholinesterase].EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte Geb. 20(1) , 28-33, (1989)
Repetitive stimulation of the median nerve elicited a so far unknown course of the muscle action potentials in four patients with organophosphate intoxications. The amplitude of the initial muscle act...