UCL 2077
Modify Date: 2025-08-25 21:38:31
UCL 2077 structure
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Common Name | UCL 2077 | ||
|---|---|---|---|---|
| CAS Number | 918311-87-2 | Molecular Weight | 350.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H22N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of UCL 2077UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2]. |
| Name | 1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine |
|---|---|
| Synonym | More Synonyms |
| Description | UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2]. |
|---|---|
| Related Catalog | |
| Target |
sAHP[1]. |
| References |
| Molecular Formula | C25H22N2 |
|---|---|
| Molecular Weight | 350.46 |
| Exact Mass | 350.17800 |
| PSA | 24.92000 |
| LogP | 5.55420 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
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Ca2+-dependent and Na+-dependent K+ conductances contribute to a slow AHP in thalamic paraventricular nucleus neurons: a novel target for orexin receptors.
J. Neurophysiol. 104(4) , 2052-62, (2010) Thalamic paraventricular nucleus (PVT) neurons exhibit a postburst apamin-resistant slow afterhyperpolarization (sAHP) that is unique to midline thalamus, displays activity dependence, and is abolishe... |
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Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).
Mol. Pharmacol. 70(5) , 1494-502, (2006) The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not bee... |
| hms3261b11 |
| hms3269l03 |
| ucl 2077 |