UCL 1684

Modify Date: 2025-08-25 14:21:24

UCL 1684 structure	Common Name	UCL 1684
	CAS Number	199934-16-2	Molecular Weight	720.66000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₈H₃₀F₆N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of UCL 1684

UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3].

Name	UCL 1684,6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo[b,n][1,5,12,16]tetraazacyclotricosine-5,13-diiumdibromide
Synonym	More Synonyms

Description	UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Potassium Channel[1]
In Vitro	UCL 1684 (dibromide) (0.5 μM; HEK cells) produces direct atrial-selective inhibition of sodium channel current (INa) and shifts SS inactivation of the cardiac sodium channels. UCL 1684 (dibromide) (0.5 μM) induces PRR, decreases V max, increases DTE, and extends the shortest S1-S1 interval[1].
In Vivo	UCL 1684 (dibromide) (3 mg/kg; i.v.) increases wenckebach cycle length to 115.0±5.1 % of baseline value[3].
References	[1]. Burashnikov A, et al. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020;76(2):164-172. [2]. Rosa JC, et al. Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel. J Med Chem. 1998;41(1):2-5. [3]. Diness JG, et al. Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition. Hypertension. 2011;57(6):1129-1135.

Molecular Formula	C₃₈H₃₀F₆N₄O₄
Molecular Weight	720.66000
Exact Mass	720.21700
PSA	112.08000
LogP	5.07540

ucl 1684

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UCL 1684
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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DC Chemicals Limited
China
Product Name: UCL 1684 dibromide
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6,12,19,20,25,26-HEXAHYDRO-5,27:13,18:21,24-TRIETHENO-11,7-METHENO-7H-DIBENZO [B,N] [1,5,12,16]TETRAAZACYCLOTRICOSINE-5,13-DIIUM DITRIFLUOROACETATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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UCL 1684

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