CEP-9722
Modify Date: 2024-01-10 16:16:40
CEP-9722 structure
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Common Name | CEP-9722 | ||
|---|---|---|---|---|
| CAS Number | 916574-83-9 | Molecular Weight | 418.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H26N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CEP-9722CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2]. |
| Name | CEP-9722 |
|---|
| Description | CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2]. |
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| Related Catalog | |
| Target |
PARP-1:20 nM (IC50) PARP-2:6 nM (IC50) |
| In Vivo | CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; for 5 days a week for 4 weeks) shows dose-dependent antitumor activity in RT4 xenografts; 200 mg/kg daily is better than control and 100 mg/kg is not[1]. Animal Model: Nude mice bearing subcutaneous RT4 human urothelial carcinoma (UC) tumors[1] Dosage: 100 or 200 mg/kg/day Administration: Oral gavage; once daily; for 5 days a week for 4 weeks Result: Showed dose-dependent antitumor activity in RT4 xenografts. |
| References |
| Molecular Formula | C24H26N4O3 |
|---|---|
| Molecular Weight | 418.49 |