Ropinirole

Modify Date: 2024-01-02 11:37:06

Ropinirole structure	Common Name	Ropinirole
	CAS Number	91374-21-9	Molecular Weight	260.375
	Density	1.0±0.1 g/cm3	Boiling Point	410.5±45.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₇D₇N₂O	Melting Point	243-250°C
	MSDS	N/A	Flash Point	202.0±28.7 °C

Use of Ropinirole

Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].

Name	ropinirole
Synonym	More Synonyms

Description	Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor:29 nM (Ki) hD2 Receptor:7.4 (pEC50) hD3 Receptor:8.4 (pEC50) hD4.4 Receptor:6.8 (pEC50)
In Vitro	Ropinirole has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2].
In Vivo	Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2].
References	[1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [2]. Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93.

Density	1.0±0.1 g/cm3
Boiling Point	410.5±45.0 °C at 760 mmHg
Melting Point	243-250°C
Molecular Formula	C₁₆H₁₇D₇N₂O
Molecular Weight	260.375
Flash Point	202.0±28.7 °C
Exact Mass	260.188873
PSA	32.34000
LogP	3.19
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.539

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36/37/39

Precursor 10
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DownStream 1
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