ISX-3

Modify Date: 2025-08-26 17:22:58

ISX-3 Structure
ISX-3 structure
Common Name ISX-3
CAS Number 912789-08-3 Molecular Weight 330.77
Density N/A Boiling Point N/A
Molecular Formula C16H15ClN4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ISX-3


ISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPARγ. ISX-3 has the potential for the research of osteopenia and osteoporosis[1].

 Names

Name ISX-3

 ISX-3 Biological Activity

Description ISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPARγ. ISX-3 has the potential for the research of osteopenia and osteoporosis[1].
Related Catalog
In Vitro ISX-3 (0-100,000 nM; 10 days) 显示出对脂滴积累的刺激作用和对 ALP 诱导的抑制作用[1]。 ISX-3 (50 µM; 2 days) 在存在 MDI 的情况下增加 hBMSCs 中 PPARγ 的表达[1]。 Western Blot Analysis[1] Cell Line: hBMSCs Concentration: 50 µM Incubation Time: 2 days Result: Increased the PPARγ expression level in the presence of MDI (0.5 mM isobutyl methylxanthine, 1 μM dexamethasone and 1 μM insulin).
References

[1]. Nawa K, et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74.  

 Chemical & Physical Properties

Molecular Formula C16H15ClN4O2
Molecular Weight 330.77
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