ISX-3

Names

[ Name ]:
ISX-3

Biological Activity

[Description]:

ISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPARγ. ISX-3 has the potential for the research of osteopenia and osteoporosis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

ISX-3 (0-100,000 nM; 10 days) 显示出对脂滴积累的刺激作用和对 ALP 诱导的抑制作用[1]。 ISX-3 (50 µM; 2 days) 在存在 MDI 的情况下增加 hBMSCs 中 PPARγ 的表达[1]。 Western Blot Analysis[1] Cell Line: hBMSCs Concentration: 50 µM Incubation Time: 2 days Result: Increased the PPARγ expression level in the presence of MDI (0.5 mM isobutyl methylxanthine, 1 μM dexamethasone and 1 μM insulin).

[References]

[1]. Nawa K, et al. Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: unique screening and Oncostatin M-like activity. Differentiation. 2013 Jul-Sep;86(1-2):65-74.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₅ClN₄O₂

[ Molecular Weight ]:
330.77

Related Compounds

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