832115-62-5
832115-62-5 structure
- Name: Isoxazole 9 (ISX-9)
- Chemical Name: N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
- CAS Number: 832115-62-5
- Molecular Formula: C11H10N2O2S
- Molecular Weight: 234.274
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2017-05-14 02:12:01
- Modify Date: 2024-01-08 13:50:33
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ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.
| Name | N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide |
|---|---|
| Synonyms |
N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
3-Isoxazolecarboxamide, N-cyclopropyl-5-(2-thienyl)- ISX 9 Isoxazole 9 ISX-9 |
| Description | ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 468.1±35.0 °C at 760 mmHg |
| Molecular Formula | C11H10N2O2S |
| Molecular Weight | 234.274 |
| Flash Point | 236.9±25.9 °C |
| Exact Mass | 234.046295 |
| PSA | 86.86000 |
| LogP | 1.25 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.637 |
| Storage condition | -20℃ |
|
~62%
832115-62-5 |
| Literature: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Patent: US2009/36451 A1, 2009 ; Location in patent: Page/Page column 32 ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |