thyroglobulin, human

Modify Date: 2024-01-02 18:42:42

thyroglobulin, human Structure
thyroglobulin, human structure
Common Name thyroglobulin, human
CAS Number 9010-34-8 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS USA Flash Point N/A

 Use of thyroglobulin, human


Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle[1].

 Names

Name Thyroglobulin,from Bovine Thyroid Gland
Synonym More Synonyms

 thyroglobulin, human Biological Activity

Description Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle[1].
Related Catalog
Target

others

References

[1]. Cintia E Citterio, et al. The role of thyroglobulin in thyroid hormonogenesis. Nat Rev Endocrinol. 2019 Jun;15(6):323-338.  

 Chemical & Physical Properties

Appearance of Characters powder | white to tan
Storage condition −20°C
Water Solubility H2O: 20 mg/mL

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles76

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Amyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host protein.

PLoS ONE 7 , e31253, (2012)

Nine neurodegenerative disorders, called polyglutamine (polyQ) diseases, are characterized by the formation of intranuclear amyloid-like aggregates by nine proteins containing a polyQ tract above a th...

The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.

J. Immunol. 193(1) , 96-101, (2014)

Enhanced iodide ingestion is known to accelerate the incidence and severity of spontaneous autoimmune thyroiditis [iodide-accelerated spontaneous autoimmune thyroiditis (ISAT)] in NOD.H2(h4) mice. CD4...

Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008.

Sci. Total Environ. 445-446 , 299-305, (2013)

Triclosan and parabens are broad spectrum antimicrobials used in a range of consumer products. In vitro and animal studies have suggested the potential for these compounds to disrupt thyroid function,...

 Synonyms

MFCD00132429