thyroglobulin, human

Names

[ Name ]:
thyroglobulin, human

[Synonym ]:
MFCD00132429

Biological Activity

[Description]:

Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

others

[References]

[1]. Cintia E Citterio, et al. The role of thyroglobulin in thyroid hormonogenesis. Nat Rev Endocrinol. 2019 Jun;15(6):323-338.

Chemical & Physical Properties

[ Appearance of Characters ]:
powder | white to tan

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 20 mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Amyloid-like fibril formation by polyQ proteins: a critical balance between the polyQ length and the constraints imposed by the host protein.

PLoS ONE 7 , e31253, (2012)

Nine neurodegenerative disorders, called polyglutamine (polyQ) diseases, are characterized by the formation of intranuclear amyloid-like aggregates by nine proteins containing a polyQ tract above a th...

The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.

J. Immunol. 193(1) , 96-101, (2014)

Enhanced iodide ingestion is known to accelerate the incidence and severity of spontaneous autoimmune thyroiditis [iodide-accelerated spontaneous autoimmune thyroiditis (ISAT)] in NOD.H2(h4) mice. CD4...

Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008.

Sci. Total Environ. 445-446 , 299-305, (2013)

Triclosan and parabens are broad spectrum antimicrobials used in a range of consumer products. In vitro and animal studies have suggested the potential for these compounds to disrupt thyroid function,...