Detomidine hydrochloride

Modify Date: 2024-01-07 08:11:08

Detomidine hydrochloride structure	Common Name	Detomidine hydrochloride
	CAS Number	90038-01-0	Molecular Weight	222.714
	Density	N/A	Boiling Point	386.5ºC at 760mmHg
	Molecular Formula	C₁₂H₁₅ClN₂	Melting Point	160ºC
	MSDS	N/A	Flash Point	200.6ºC

Use of Detomidine hydrochloride

Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.

Name	Detomidine Hydrochloride
Synonym	More Synonyms

Description	Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in horses.Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Virtanen R, et al. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.

Boiling Point	386.5ºC at 760mmHg
Melting Point	160ºC
Molecular Formula	C₁₂H₁₅ClN₂
Molecular Weight	222.714
Flash Point	200.6ºC
Exact Mass	222.092377
PSA	28.68000
LogP	3.41930

Detomidine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5160000

CHEMICAL NAME :: 1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 90038-01-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H14-N2.Cl-H

MOLECULAR WEIGHT :: 222.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4443466

Hazard Codes	Xi
RIDADR	UN 2811 6.1 / PGIII
RTECS	NI5160000
HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Atipamezole antagonism of an ACTH stimulation test in ponies sedated with detomidine.

J. Vet. Pharmacol. Ther. 34(5) , 508-11, (2011)

Influence of detomidine and xylazine on spleen dimensions and on splenic response to epinephrine infusion in healthy adult horses.

Vet. Anaesth. Analg. 40(4) , 375-81, (2013)

To compare the changes in splenic length and thickness and in packed cell volume (PCV) following detomidine or xylazine administration and subsequent epinephrine infusion.Spleen relaxation occurs foll...

Comparison of the mechanical hypoalgesic effects of five α2-adrenoceptor agonists in donkeys.

Vet. Rec. 173(12) , 294, (2013)

Pharmacological pain management is necessary under many clinical situations, but in donkeys little information on analgesic drugs is available. This controlled, randomised, crossover, Latin-square, op...

1H-Imidazole, 5-[(2,3-dimethylphenyl)methyl]-, hydrochloride (1:1)

5-[(2,3-dimethylphenyl)methyl]-1H-imidazole,hydrochloride

4-(2,3-Dimethylbenzyl)-1H-imidazole hydrochloride (1:1)

DC Chemicals Limited
China
Product Name: Detomidine hydrochloride
Price: $350.0/100mg $500.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Detomidine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Detomidine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Detomidine hydrochloride

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