Aceclofenac
Modify Date: 2024-01-02 19:21:58
Aceclofenac structure
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Common Name | Aceclofenac | ||
|---|---|---|---|---|
| CAS Number | 89796-99-6 | Molecular Weight | 354.185 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 486.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H13Cl2NO4 | Melting Point | 149-153°C | |
| MSDS | Chinese USA | Flash Point | 247.8±28.7 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
Use of AceclofenacAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1]. |
| Name | aceclofenac |
|---|---|
| Synonym | More Synonyms |
| Description | Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1]. |
|---|---|
| Related Catalog | |
| Target |
COX-2:3 μM (IC50) COX-1:7.3 μM (IC50) |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 486.0±45.0 °C at 760 mmHg |
| Melting Point | 149-153°C |
| Molecular Formula | C16H13Cl2NO4 |
| Molecular Weight | 354.185 |
| Flash Point | 247.8±28.7 °C |
| Exact Mass | 353.022156 |
| PSA | 75.63000 |
| LogP | 4.16 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.639 |
| Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319-H410 |
| Precautionary Statements | P273-P301 + P310-P305 + P351 + P338-P501 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | 2811.0 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| HS Code | 2922509090 |
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Aceclofenac CAS#:89796-99-6 |
| Literature: US2004/24057 A1, ; Page/Page column 53 ; |
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~%
Aceclofenac CAS#:89796-99-6 |
| Literature: Journal of Crystallographic and Spectroscopic Research, , vol. 22, # 3 p. 323 - 328 |
|
~%
Aceclofenac CAS#:89796-99-6 |
| Literature: Journal of Crystallographic and Spectroscopic Research, , vol. 22, # 3 p. 323 - 328 |
CAS#:139272-66-5
CAS#:15307-86-5| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Development and implication of methodology for aceclofenac in pure and pharmaceutical formulations by microwave assisted spectrophotometry.
Pak. J. Pharm. Sci. 26(1) , 169-73, (2013) A simple, fast and cost effective method for determination of aceclofenac in pure and tablet formulations has been developed and validated. The method is based on formation of stable blue coloured com... |
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Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.
Int. J. Pharm. 438(1-2) , 117-22, (2012) Electrospun composite zein/eudragit nanofibers were developed with an aim to deliver two different classes of drugs simultaneously that would restrict/compensate the adverse effects of non-steroidal a... |
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Absolute bioavailability and metabolism of aceclofenac in rats.
Arch. Pharm. Res. 38(1) , 68-72, (2015) Aceclofenac is one of the most popular analgesic and anti-inflammatory drugs used for the relief of pain, rheumatoid arthritis, and osteoarthritis. To date, no intravenous preparation of aceclofenac h... |
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