5-(Carboxy(hydroxy)methyl)uridine methyl ester

Modify Date: 2024-09-18 15:10:11

5-(Carboxy(hydroxy)methyl)uridine methyl ester Structure
5-(Carboxy(hydroxy)methyl)uridine methyl ester structure
Common Name 5-(Carboxy(hydroxy)methyl)uridine methyl ester
CAS Number 89665-83-8 Molecular Weight 332.26300
Density N/A Boiling Point N/A
Molecular Formula C12H16N2O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-(Carboxy(hydroxy)methyl)uridine methyl ester


(S)-mchm5U is a hydroxylated form of mcm5U, may be present in tRNA from the silkworm Bombyx mori. (S)-mchm5U may be present also in mammalian tRNA, and that the ALKBH8 oxygenase could be responsible for its formation. (S)-mchm5U can be used for RNA modification synthesis[1].

 Names

Name methyl 2-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-2-hydroxyacetate
Synonym More Synonyms

  Biological Activity

Description (S)-mchm5U is a hydroxylated form of mcm5U, may be present in tRNA from the silkworm Bombyx mori. (S)-mchm5U may be present also in mammalian tRNA, and that the ALKBH8 oxygenase could be responsible for its formation. (S)-mchm5U can be used for RNA modification synthesis[1].
Related Catalog
References

[1]. van den Born E, et al. ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nat Commun. 2011 Feb 1;2:172.  

 Chemical & Physical Properties

Molecular Formula C12H16N2O9
Molecular Weight 332.26300
Exact Mass 332.08600
PSA 171.57000
InChIKey JNVLKTZUCGRYNN-LQGIRWEJSA-N
SMILES COC(=O)C(O)c1cn(C2OC(CO)C(O)C2O)c(=O)[nH]c1=O

 Synonyms

Chmu-methyl ester
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